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Task 14.6

How does deep learning work? An example of a deep learning network is AlphaGo – can

you find the movie?

Task 14.7

What is meant by a bioinformatics prediction model that is a classification model (feel free

to explain with an example)?

Task 14.8

Explain PCA, clustering, linear regression, logistic regression, and survival time analysis.

What are the similarities and differences?

Useful Tools and Web Links

• Bent Larsen:

https://www.chessgames.com/player/bent_larsen.html

* Of course you can also look at completely different chess games and players at

this link.

• Deep Junior (chess computer):

https://www.hiarcs.com/pc-­chess-­deep-­junior.htm

* Deep Junior 13.8 was the best chess computer at the World Computer

Championship in 2013. Authors are Amir Ban and Shay Bushinsky. The prefix

Deep refers to the correspondingly strong multiprocessor version for

tournaments.

• Game of Go (won by computer):

https://www.nature.com/nature/journal/v529/n7587/full/nature16961.html

• TMHMM (hidden Markov model predicts membranes):

https://www.cbs.dtu.dk/services/TMHMM/

• SignalP (neural network predicts signal peptides or secretion):

https://www.cbs.dtu.dk/services/SignalP/

Literature

Cao B, Wang Y, Wen D et al (2020) A trial of Lopinavir-Ritonavir in adults hospitalized with severe

covid-19. N Engl J Med 382:1787–1799. https://doi.org/10.1056/NEJMoa2001282

Dandekar T, Argos P (1994) Folding the main chain of small proteins with the genetic algorithm. J

Mol Biol 236(3):844–861

Dandekar T, Argos P (1996) Identifying the tertiary fold of small proteins with different topologies

from sequence and secondary structure using the genetic algorithm and extended criteria specific

for strand regions. J Mol Biol 256(3):645–660

Literature